The Daunting Pandemic

swine-fluIn recent years several disease outbreaks like Ebola virus, Avian Influenza A virus, Middle East Respiratory Syndrome coronavirus (MERS-CoV) have paralyzed the lives of millions across the globe. The current outburst of Influenza virus A, Swine Flu has claimed and is still claiming thousands of lives along with a high morbidity rate. In the year 2009, the virus was first detected in Mexico and started intruding to other parts of the United States and gradually to the entire world. HIN1 upsurge claimed nearly 50,000 lives worldwide. Looking at the gravity of the situation the World Health Organization (WHO) has declared it a ‘pandemic. ’

In India, the situation is no better. This year the flu virus has claimed as many as 1000 lives so far. Till now a total of 22,186 cases have been registered, and the figure increases with each passing day! The situation is getting worse with each passing year as well. In current year approximately 1094 deaths and 22,196 cases have been observed as compared to 265 deaths and 1786 swine flu cases in the year 2016. The highest number of people succumbing to the deadly viral infection have been reported in Maharashtra (467), followed by Gujarat (269), Kerala (73) and Rajasthan (69). The disease is slowly gripping its roots to other parts of the nation as well.

What is Swine flu?

Swine Flu is a contagious respiratory infection caused by one of the several strains of the Influenza Virus. The virus belongs to the family Orthomyxoviridae.

These RNA viruses have a genome that is approximately 13.5 kbps in size and is segmented into 8 coding regions that code for 11 different proteins:

  1. Envelope proteins: Hemagglutinin (HA) and Neuraminidase (NA).
  2. RNA Basic Polymerase: PA, PB-1, PB1-F2, and PB-2.
  3. Matrix Proteins: M1 and M2.
  4. Non-structural Proteins: NS-1 and NS-2.

HA and NA are the major surface glycoproteins that are responsible for viral attachment, replication, and pathogenesis and thus, are the main targets for antiviral drugs. These pathogens fast mutate into new strains by re-assorting the HA and NA genes and this is the main roadblock in the treatment of flu virush1n1 virus str.jpg

Image source: www.dreamstime.com

The RNA viruses are classified into three genera based on their antigenic differences1 in their nucleoprotein and matrix protein- Influenza virus A, Influenza virus B and Influenza virus C.

Influenza virus A cause severe flu outbreaks in domestic poultry and are the most virulent human pathogens that are mainly responsible for giving rise to human influenza pandemics. They are further subdivided into different serotypes2 based on the antibody response to these viruses- H1N1 (Swine flu pandemic 2009), H1N2, H2N2, H3N2, H5N1, H7N7, H7N2, H7N3, H10N7, and H7N9.

Influenza virus B mainly infects humans but is less pathogenic than Type A. They do not result in pandemics.

Influenza virus C targets humans, dogs, and pigs but they are less common than the other types and cause mild disease.

How the virus does attacks and invades the host body?

When the virus enters the host body it attaches to the sialyl moiety3 of the target cell surface. This binding is highly specific in nature. The whole invasion process can be summarised below:

Viral particles attach to the sialyl moiety of the host cell

Viral particles then enter the host cell via the process of endocytosis4

Transcription of the viral RNA genome by RNA polymerase

m-RNA produced

m-RNA is processed into ss-RNA using host cell machinery

Assembly, maturation, production, and release of new viral progenies.

As the viral progenies are released they target other cells and this marks the onset of infection. The incubation period5 of the flu is 2-4 days.

Once the incubation period is over the symptoms begin to appear. The common signs of the diseased state are chills, fever, running nose, sore throat, body aches, nausea, vomiting, diarrhea, and fatigue.

Pigs are the main reservoir of the virus and act as an intermediate host for interspecies transmission and genetic variation. The virus strains that infect humans are different from the strains that attack the swine population. It spreads through saliva and mucus particles that are released when an infected person or pig coughs, sneezes or touching the germ-covered surface or eyes. SWINE FLU IS NOT CAUSED BY EATING PORK MEAT.

What are the possible treatments available?

The treatment regimen includes drugs that precisely inhibit progeny virion production. These drugs are Zanamivir (Relenza), Peramivir (Rapivab), Favipiravir Oseltamivir (Tamiflu). The first three drugs are administered intravenously while Tamiflu is given orally. Many times combination drug therapy is also administered for effective treatments. E.g. Favipiravir is given in addition to Oseltamivir and Zanamivir. This drug amalgam efficiently inhibits the RNA polymerase of viral particles, thus, checks viral replication.

Apart from drugs Flu vaccination is the most preferred choice for reducing the risk of contracting the disease. Flu vaccines are composed of either live attenuated6 or killed viruses. When given to the body it triggers the immune system to produce antibodies against the virus and thus, protects the host.

The traditional flu vaccines that are made are protective against two influenza virus A strains namely H1N1&H3N2 and an Influenza virus B. This is trivalent vaccine5 (Vaccine that has three different antigenic sites). The other is quadrivalent that protects against the above three vaccines and an additional Influenza virus B strain. The Flu vaccine can be administered using either a needle or a nasal spray. The flu vaccine given using a needle (Flu Shot) are made in two ways: either using viruses that are inactivated or recombinant flu vaccine. The nasal spray flu vaccine contains live attenuated viruses. Both Flu Shot and Nasal spray flu vaccine are associated with some mild and short-lasting side effects-running nose, headaches, muscle aches, soreness, swelling at the place where vaccine is given, mild fever, to name a few. But in case if the flu vaccine causes some severe problems post vaccination then it is strongly recommended to consult the doctor.

Apart from the above vaccinations and treatments, it is of utmost importance to maintain personal hygiene and always use a hand sanitizer after coughing, sneezing or touching any of the diseased animal or person.

Footnotes:

  1. Antigenic Variations is the mechanism with the help of which the pathogen alters its surface proteins to evade host immune system.
  2. Serotype is a distinct variation among different bacterial, viral species or immune cells of different individuals based on their difference in cell surface antigens.
  3. Sialyl moieties are sialic acid entities present at the terminus of the glycosylated oligosaccharide of the host cell surface.
  4. The process of taking in any matter by the living cell through membrane invagination.
  5. A period between exposure to the infection and appearance of the first symptom.
  6. Vaccines that are created by greatly reducing the virulence of the pathogen, keeping it alive.
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Urinary Tract Infections and Antibiotics: Some points to seriously ponder on.

Treat-a-Urinary-Tract-Infection-Step-19

Image source :www.google.co.in/images

I would like all the women folk and young girls on the other side of the screen to read this article published in the magazine Popular Science.

UTIs are one of the common problems that we all have come across. Also, we know that in recent times the antibiotic resistance of the microbial community has dreaded the medical fraternity in some or the other way.  Research has been done that claims that antibiotics have made UTIs to treat a bit difficult. Bacteria being resistant to antibiotics do not flush out completely leading to re-occurrence of the infection, that is, the recurrent UTIs (RUTI). But anti biotic use is not only the sole reason behind RUTIs. There are other reasons too that are cited in the article. Follow the link below.

http://www.popsci.com/uti-recurrent-antibiotic-resistance#page-2

 

Its National Nutrition Week.

The first week of September is marked as National Nutrition Week. This year the motto of the programme is Better Child Health, which is very crucial for everyone and especially the expecting and new mums. It is, in fact, necessary for them to know about the importance of proper nutrition and dietary facts for the future generation as well as about themselves which would help in building a healthier and stable society.

follow the links below.

http://www.ndtv.com/food/national-nutrition-week-2017-a-quick-guide-to-infant-feeding-essentials-1745861

https://www.nhp.gov.in/

 

Back with a bang!

Hello everyone!

From past several months, I was not active on my blog. The reason being I was enjoying the new bond of love with my firstborn. Though my followers’ list is not long yet for the kind ones who’ve been reading my posts here’s a good news- AM BACK !

I would try my level best to keep posting and updating you with the latest breakthroughs in the biological world, however, the number of posts may be a handful – all thanks to my zestful, perky young boy, nonetheless, I’ll make sure you will enjoy.

Signing off,

Keep reading , Keep learning!

Curd: A probiotic supplement that help reduce the risk of Breast Cancer.

curd.jpgCurd is known to be one of the best supplements of good bacteria and also for its rich calcium content. It helps improve digestion. Recent studies showed that it also helps reduce the risk of breast cancer as the good health-promoting bacteria it provides with, Lactobacillus and Streptococcus, possess anti-carcinogenic properties.

http://food.ndtv.com/health/another-reason-to-eat-curd-daily-it-may-reduce-breast-cancer-risk-1423922

Gene mutation causing Multiple Sclerosis cracked.

ms.jpg

Investigators at the University of British Columbia (UBC) in Vancouver have cracked down the first gene mutation linked to the occurrence of Multiple Sclerosis (MS). MS is a neurodegenerative disorder wherein  the immune system attacks the myelin sheath of the nerves which eventually hinders the flow of information between brain and the body. The brain and the spinal cord are majorly affected.

The researchers found a missense mutation of the NR1H3 gene from the families with multiple cases of MS and concluded it to be one of the major reasons for the decreased myelin sheath production.

For more details click

https://www.sciencedaily.com/releases/2016/06/160601132134.htm